听力与言语-语言病理学

行为科学

医学伦理学

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  • A phase II study of weekly docetaxel for patients with advanced or recurrent cancer of the cervix.

    abstract:BACKGROUND/AIMS:A phase II study was conducted to assess the activity and toxicity of weekly docetaxel in patients with advanced or recurrent cancer of the cervix. METHODS:Eligible patients were required to have measurable disease with adequate performance status, bone marrow, renal and hepatic function. Patients were...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000106489

    authors: Pearl ML,Johnston CM,McMeekin DS

    更新日期:2007-01-01 00:00:00

  • Prolonged postpartum urinary retention: the importance of asking the right questions at the right time.

    abstract::The pathophysiology of postpartum urinary retention (PUR) is still unclear. The prevalence rate varies with the definition used and the literature discusses various risk factors. Bladder catheterization is the treatment of choice, but the best way to do it is not ascertained. Long-term sequelae seem to be rare. There ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000099306

    authors: Humburg J,Holzgreve W,Hoesli I

    更新日期:2007-01-01 00:00:00

  • Human papillomavirus DNA in triple neoplasms of the cervix, perianus and ureter in one woman.

    abstract:BACKGROUND:Multiple malignancies of the urogenital tract have been reported. We investigated the etiological role of human papillomavirus (HPV) in the pathogenesis of urogenital cancers. CASE:We present a case of cervical squamous carcinoma in a 64-year-old woman who subsequently developed Bowen's disease in the peria...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000097139

    authors: Huang LW,Pan HS,Lin YH,Chou KY

    更新日期:2007-01-01 00:00:00

  • sCD40 ligand determined in maternal and umbilical cord blood in pregnancies complicated by pre-eclampsia with and without intrauterine growth retardation.

    abstract:OBJECTIVE:The aim of this study was determination and comparative analysis of the maternal and umbilical cord sCD40L serum levels in pregnancies complicated by pre-eclampsia with and without intrauterine growth retardation (IUGR) and in normotensive pregnancies. PATIENTS AND METHODS:The study was carried out on 16 pat...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000098316

    authors: Laskowska M,Laskowska K,Leszczyńska-Gorzelak B,Oleszczuk J

    更新日期:2007-01-01 00:00:00

  • Measurement of tension-free vaginal tape trocar insertion and exit forces.

    abstract:BACKGROUND/AIMS:This study aims to establish a model to measure the forces required for tension-free vaginal tape (TVT) trocar application using a pressure transducer. METHODS:A 3.5 x 3.5 cm pressure transducer was constructed from piezo-resistive material. The transducer digitally recorded the surface contact pressur...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000092641

    authors: Yip SK,Pang MW,Sahota DS

    更新日期:2006-01-01 00:00:00

  • Activation antigens during the proliferative and secretory phases of endometrium and early-pregnancy decidua.

    abstract:BACKGROUND:Clarifying the normal distribution of activation antigens will contribute to database construction studies of monoclonal-antibody-based therapies in endometrial disorders. METHODS:In this study, endometrial tissue samples obtained during proliferative and secretory phases and decidual samples of early pregn...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000092375

    authors: Ugur Y,Cakar AN,Beksac MS,Dagdeviren A

    更新日期:2006-01-01 00:00:00

  • Medical termination of pregnancy in acute intermittent porphyria.

    abstract::Acute intermittent porphyria is a rare autosomal dominant disease characterized by acute attacks of neuropsychiatric and neurovisceral dysfunction. In pregnancy, exacerbation of attacks in the form of seizures and acute abdomen occur due to hormonal changes. We report the case of a young woman presenting at 8 weeks of...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000091835

    authors: Sahu MT,Rajaram S,Saxena AK,Goel N,Ghumman S

    更新日期:2006-01-01 00:00:00

  • Successful treatment of deep dyspareunia and primary dysmenorrhea with laparoscopic uterosacral nerve ablation (LUNA) procedure.

    abstract::Deep dyspareunia, often described as pain resulting from pelvic thrusting during sexual intercourse, is relatively common and has many causes. To date, feasible surgical interventions for deep dyspareunia are very rare. The two procedures which have been mentioned in the literature for the treatment of deep dyspareuni...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000087562

    authors: Juang CM,Yen MS,Horng HC,Yu HC,Chang CM,Yeh JY

    更新日期:2006-01-01 00:00:00

  • Effect of membrane sweeping at term pregnancy on duration of pregnancy and labor induction: a randomized trial.

    abstract:AIM:To evaluate the efficacy of sweeping of fetal membranes for induction of labor in uncomplicated term pregnancies. METHODS:A randomized controlled trial was performed in 122 pregnant women beyond 39 weeks of gestation with no complications. The women were assigned to have their membranes swept or not (controls) for...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,随机对照试验

    doi:10.1159/000091842

    authors: Kashanian M,Akbarian A,Baradaran H,Samiee MM

    更新日期:2006-01-01 00:00:00

  • Genomewide oligonucleotide microarray analysis on placentae of pre-eclamptic pregnancies.

    abstract:OBJECTIVE:Human placentae from normal and pre-eclamptic pregnancies were evaluated for possible changes in gene expression by microarray analysis to uncover new clues for the research of the etiology of pre-eclampsia. METHODS:Placentae from five normal pregnancies and five pregnancies complicated by pre-eclampsia were...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000092857

    authors: Zhou R,Zhu Q,Wang Y,Ren Y,Zhang L,Zhou Y

    更新日期:2006-01-01 00:00:00

  • Cost-effectiveness analysis of various screening methods for osteoporosis in perimenopausal Thai women.

    abstract:OBJECTIVE:To perform a health economics analysis of 5 screening programs for osteoporosis in perimenopausal Thai women comparing two alternatives; without intervention and universal treatment without screening. DESIGN:A decision analysis was performed to evaluate five screening strategies: Dual energy X-ray absorptiom...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000092803

    authors: Panichkul S,Panichkul P,Sritara C,Tamdee D

    更新日期:2006-01-01 00:00:00

  • Inhibition of proliferation of endometrial stromal cells by trichostatin A, RU486, CDB-2914, N-acetylcysteine, and ICI 182780.

    abstract:BACKGROUND:All current major medications in treating endometriosis are effective in treating pain, most likely through suppression of proliferation of the implants, yet their effectiveness is relatively short term and they all have many undesirable, and sometimes severe, side effects. There is pressing need for novel, ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000093975

    authors: Wu Y,Guo SW

    更新日期:2006-01-01 00:00:00

  • Association of endometriosis risk and genetic polymorphisms involving sex steroid biosynthesis and their receptors: a meta-analysis.

    abstract::Endometriosis is a sex steroids-dependent disease. It has been postulated that certain genetic polymorphisms involved in sex steroids biosynthesis and metabolisms may be associated with increased risk of developing endometriosis. Despite a deluge of reports of positive associations of endometriosis with numerous polym...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,meta分析,评审

    doi:10.1159/000089011

    authors: Guo SW

    更新日期:2006-01-01 00:00:00

  • Vaginal ultrasonographic and hysterosonographic evaluation of the low transverse incision after caesarean section: correlation with gynaecological symptoms.

    abstract:AIM:We investigated whether there is a correlation between morphological changes of the lower uterine segment after caesarean section (CS), visualized by means of either a transvaginal sonography (TVS) or a sonohysterography (SHG), and the frequency of abnormal uterine bleedings reported by the women. METHODS:By means...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000091497

    authors: Menada Valenzano M,Lijoi D,Mistrangelo E,Costantini S,Ragni N

    更新日期:2006-01-01 00:00:00

  • Association of apolipoprotein J gene 866C-->T polymorphism with preeclampsia and essential hypertension.

    abstract::The etiology of preeclampsia (PE) is unknown, but endothelial cell injury plays a pivotal role. Moreover, there is a significantly positive association between PE and later hypertension. Apolipoprotein J (apo J) plays an important role in stabilizing cell membranes at diverse fluid-tissue interfaces and might protect ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000086056

    authors: Chen M,Yuan Z,Shan K

    更新日期:2005-01-01 00:00:00

  • Accelerated bone turnover in pregnant women with McCune-Albright syndrome.

    abstract::Bone turnover in pregnant women with McCune-Albright syndrome may be affected by both the syndrome and pregnancy. This study evaluated changes in biochemical bone turnover markers in pregnant women with the syndrome. Serum calcium, phosphorus, 1,25-dihydroxyvitamin D (1,25-(OH)2D), intact osteocalcin (I-OC) and alkali...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000085535

    authors: Osada H,Sakamoto R,Seki K,Sekiya S

    更新日期:2005-01-01 00:00:00

  • Subcutaneous implantation of pure crystalline estradiol pellets for conception control.

    abstract:OBJECTIVES:Assessment of the contraceptive effectiveness of pure estradiol pellets implanted annually under the skin, thus avoiding the 'first passage phenomenon' through the liver, using a modification of Emperaire and Greenblatt's method. STUDY DESIGN:228 women wishing birth control for 1 year or more were included....

    journal_title:Gynecologic and obstetric investigation

    pub_type: 临床试验,杂志文章

    doi:10.1159/000082652

    authors: Oettinger M,Barak S,Oettinger-Barak O,Ophira E

    更新日期:2005-01-01 00:00:00

  • Altered metabolic profiles among older mothers with a history of preeclampsia.

    abstract::Preeclampsia has been linked to increased risk for cardiovascular disease and, more recently, to reduced risk for breast cancer later in life. The altered chronic disease risk associated with prior preeclampsia may reflect underlying metabolic differences. In this case-control study, we examined the metabolic profiles...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000084146

    authors: Innes KE,Weitzel L,Laudenslager M

    更新日期:2005-01-01 00:00:00

  • Fimbrio-ovarian relationship in unexplained infertility.

    abstract:INTRODUCTION:The role of defective fimbrio-ovarian relation in cases of unexplained infertility has not been extensively studied. The aim of the study was to assess the role of fimbrio-ovarian relation as an investigative modality in women with unexplained infertility. We also aimed to evaluate the efficacy of superovu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000086004

    authors: Roy KK,Hegde P,Banerjee K,Malhotra N,Nayyar B,Deka D,Kumar S

    更新日期:2005-01-01 00:00:00

  • Mucocele of the vermiform appendix with sonographic appearance of an adnexal mass.

    abstract::Mucocele of the vermiform appendix is caused by mucus retention in its lumen, due to obstruction or hyperproduction. Appendiceal malignancy can be the underlying cause, making accurate preoperative diagnosis imperative. In women, it can sometimes present as an adnexal mass. A rare case of an appendiceal mucocele is pr...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000083680

    authors: Dragoumis K,Mikos T,Zafrakas M,Assimakopoulos E,Venizelos I,Demertzidis H,Bontis J

    更新日期:2005-01-01 00:00:00

  • Transvaginal ultrasonography of the endometrium in postmenopausal Japanese women.

    abstract:AIMS:To determine the cut-off level of endometrial thickness for detecting endometrial disease on a large scale of screening and to examine the usefulness of transvaginal ultrasonography (TVS) for endometrial disease screening in asymptomatic postmenopausal Japanese women. METHODS:The study involved 1,400 postmenopaus...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000087375

    authors: Tsuda H,Nakamura H,Inoue T,Kawamura N,Adachi K,Bandera CA

    更新日期:2005-01-01 00:00:00

  • Prenatal diagnosis of minute supernumerary marker chromosomes.

    abstract::The identification of supernumerary marker chromosomes (SMC) at prenatal diagnosis is problematic, particularly for the prediction of phenotype. The assessment of phenotypic risk is based on the size, morphology and origin of the SMC. Fluorescence in situ hybridization (FISH) characterization and family studies are al...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000083482

    authors: Cotter PD,Drexler K,Corley AL,Covert SM,Moland JS,Govberg IJ,Norton ME

    更新日期:2005-01-01 00:00:00

  • Should we continue performing intrauterine inseminations in the year 2004?

    abstract::This review summarizes the existing evidence regarding intrauterine insemination (IUI) as a treatment for cervical hostility, male and unexplained subfertility. IUI in natural cycles has been proven effective in patients with cervical hostility and moderate male subfertility. IUI in cycles with mild ovarian hyperstimu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000080492

    authors: Cohlen BJ

    更新日期:2005-01-01 00:00:00

  • Human amniotic fluid glycoproteins expressing sialyl Lewis carbohydrate antigens stimulate progesterone production in human trophoblasts in vitro.

    abstract:BACKGROUND:Progesterone is thought to mediate immune modulator effects by regulating uterine responsiveness. The aim of the study was to clarify the effect of transferrin and glycodelin A (former name PP14) as sialyl Lewis X-expressing glycoproteins on the release of progesterone by trophoblast cells in vitro. METHODS...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000080073

    authors: Jeschke U,Mylonas I,Richter DU,Streu A,Müller H,Briese V,Friese K

    更新日期:2004-01-01 00:00:00

  • Insulin-like growth factor 1 receptor mRNA expression and autophosphorylation in human myometrium and leiomyoma.

    abstract::Uterine leiomyomas are the most common tumors of the genital tract. Growth factors seem to be implicated in the development of leiomyoma. The aim of this study was to determine insulin-like growth factor 1 receptor (IGF-1-R) mRNA levels and IGF-1-R tyrosine kinase activity in normal myometrium and leiomyoma. Plasma me...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000076690

    authors: Martin Chaves EB,Brum IS,Stoll J,Capp E,Corleta Hv

    更新日期:2004-01-01 00:00:00

  • Magnetic resonance spectroscopy features of uterine leiomyomas.

    abstract:OBJECTIVE:The purpose of this study is to investigate the in vivo magnetic resonance spectroscopy features of uterine leiomyomas using long echo time and to characterize the spectral patterns of these lesions. METHODS:We calculated metabolites in 15 patients with uterine leiomyomas and myometrium of 20 healthy control...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000080020

    authors: Celik O,Sarac K,Hascalik S,Alkan A,Mizrak B,Yologlu S

    更新日期:2004-01-01 00:00:00

  • Gram-negative bacterial endotoxin- induced infertility: a birds eye view.

    abstract::Alleviation of infertility on the one hand and development of improved methods of contraception on the other are global concerns to woman's health. The molecular signals that regulate implantation are of clinical relevance since understanding the nature of these signals may lead to strategies to correct implantation f...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000076761

    authors: Deb K,Chatturvedi MM,Jaiswal YK

    更新日期:2004-01-01 00:00:00

  • Nasal bone measurement during the 1st trimester: is it useful?

    abstract::The aim of this study was to present our preliminary data about nasal bone measurements at 11-14 weeks of pregnancy. This study was conducted in our prenatal unit between 2000 and 2003. A total of 642 pregnant women (single pregnancies) were enrolled into the study. During the first trimester of pregnancy, crown-rump ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000078499

    authors: Kelekci S,Yazicioğlu HF,Oguz S,Inan I,Yilmaz B,Sönmez S

    更新日期:2004-01-01 00:00:00

  • The prevalence of anti-phospholipid antibodies in a selected population of Kenyan women and development of a non-human primate model.

    abstract::The mechanisms by which anti-phospholipid antibodies (aPLs) may induce pregnancy losses, intrauterine growth retardation and pregnancy-induced hypertension are not clearly understood. Moreover, there is a controversy regarding the possible direct effects of these antibodies on the physiology of the placenta since the ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:

    authors: Mwenda JM,Machoki JM,Omollo E,Galo M,Langat DK

    更新日期:2004-01-01 00:00:00

  • Monochorionic triplets following intracytoplasmic sperm injection: a report of two consecutive cases.

    abstract::Monochorionic triplet pregnancies are very rare. Here we report 2 cases of multiple pregnancies with monochorionic triplets following intracytoplasmic sperm injection (ICSI) and day 3 embryo transfer. The 2 women concomitantly underwent controlled ovarian hyperstimulation due to male factor infertility. Following oocy...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000076786

    authors: Ulug U,Jozwiak EA,Mesut A,Bener F,Bahceci M

    更新日期:2004-01-01 00:00:00

  • Factors affecting sexual life during pregnancy in eastern Turkey.

    abstract::This is a descriptive and cross-sectional study aiming to determine the factors affecting sexual life in pregnant women. The study was carried out in 238 women in Malatya, Turkey. It was found that 61.4% regarded coitus as a risk during pregnancy, 31.9% did not have any knowledge about this matter. In 81.5% sexual lif...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000075582

    authors: Eryilmaz G,Ege E,Zincir H

    更新日期:2004-01-01 00:00:00

  • Peritoneal fluid concentrations of ciliary neurotrophic factor, a gp130 cytokine, in women with endometriosis.

    abstract::Ciliary neurotrophic factor (CNTF) is a gp130 neuroregulatory cytokine belonging to the interleukin-6-type cytokine superfamily. Several lines of evidence suggest that the concentrations of interleukin-6 are elevated in the peritoneal fluid of endometriosis patients. To our knowledge, no study on whether this might al...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000072694

    authors: Suzumori N,Suzumori K

    更新日期:2003-01-01 00:00:00

  • Conventional and computerized antepartum telecardiotocography. Experienced and inexperienced observers versus computerized analysis.

    abstract::The study assessed the agreement in cardiotocogram interpretation between the 2CTG computerized system and experienced and inexperienced observers involved in a telecardiotocography project called 'TOCOMAT'. Both observers and computer analyzed FHR baseline, FHR variability, and number of large accelerations and of de...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000068955

    authors: Di Lieto A,Giani U,Campanile M,De Falco M,Scaramellino M,Papa R

    更新日期:2003-01-01 00:00:00

  • Antimicrobial activity of human follicular fluids.

    abstract::The aim of this study was to explore the antimicrobial activity of human follicular fluid (HFF), to test the hypothesis that different strains of the same bacterial species could display different patterns of susceptibility to antimicrobial action of HFF, and to preliminarily investigate the possible mechanism of anti...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000074103

    authors: Stepanović S,Djukić S,Veljković M,Arsić B,Garalejić E,Ranin L

    更新日期:2003-01-01 00:00:00

  • Modified hysteroscopic myomectomy of large submucous fibroids.

    abstract:OBJECTIVE:To compare the efficacy, feasibility, operative time and possible complications of a modified technique of hysteroscopic removal of large submucus myomata versus traditional morcellation technique, and to assess the efficacy of preoperative sonohysterography (SHG). DESIGN:A prospective comparative study. SE...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000074451

    authors: Darwish A

    更新日期:2003-01-01 00:00:00

  • Obstetric outcome in women with endometriosis--a matched case-control study.

    abstract:BACKGROUND:Immunological deficiencies, altered angiogenic activity, infiltrative potential and growth factors are plausible factors behind endometriosis. The aim of this study was to determine whether endometriosis interferes with the course or outcome of pregnancy. STUDY DESIGN:In this matched case-control study, we ...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000074815

    authors: Kortelahti M,Anttila MA,Hippeläinen MI,Heinonen ST

    更新日期:2003-01-01 00:00:00

  • Tension-free vaginal tape procedure: an effective minimally invasive operation for the treatment of recurrent stress urinary incontinence?

    abstract::The aim of this study was to evaluate the results of tension-free vaginal tape (TVT) surgery in women with recurrent stress urinary incontinence (SUI). Fifty-one women with recurrent SUI were treated with TVT and followed prospectively for a minimum of 2 years according to a protocol. Twenty percent of the women had a...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000072942

    authors: Kuuva N,Nilsson CG

    更新日期:2003-01-01 00:00:00

  • Positron emission tomography with FDG in the detection of peritoneal and retroperitoneal metastases of ovarian cancer.

    abstract:OBJECTIVE:The aim of this prospective study was to evaluate (18)F-FDG-PET, in comparison with CT, for the detection of peritoneal and retroperitoneal metastases of ovarian cancer. METHODOLOGY:13 patients with primary (n = 7) or recurrent (n = 6) ovarian cancer underwent an attenuation-corrected (18)F-FDG-PET of the ab...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000071525

    authors: Drieskens O,Stroobants S,Gysen M,Vandenbosch G,Mortelmans L,Vergote I

    更新日期:2003-01-01 00:00:00

  • Spontaneous expulsion of a Filshie clip through the anterior abdominal wall.

    abstract::Tubal occlusion using Filshie clip is one of the most commonly performed operations for female sterilization. It is usually a simple and safe procedure, and operative complications are uncommon. We report a rare case of spontaneous expulsion of a Filshie clip through the anterior abdominal wall 5 years after steriliza...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章,评审

    doi:10.1159/000070615

    authors: Lok IH,Lo KW,Ng JS,Tsui MH,Yip SK

    更新日期:2003-01-01 00:00:00

  • Does cord presentation on ultrasound predict cord prolapse?

    abstract:OBJECTIVE:To study the association of umbilical cord presentation found on antenatal ultrasound and the incidence of cord prolapse in labor. STUDY DESIGN:We reviewed the antenatal records of all deliveries in the Mount Sinai Hospital in a 5-year period and conducted two separate retrospective studies. In the first stu...

    journal_title:Gynecologic and obstetric investigation

    pub_type: 杂志文章

    doi:10.1159/000072323

    authors: Ezra Y,Strasberg SR,Farine D

    更新日期:2003-01-01 00:00:00

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